Recombinant Human Secreted Frizzled Related Protein-1
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BackgroundSecreted Frizzled Related Protein-1 also known as SFRP1 is a member of the secreted frizzled-related proteins (sFRPs) which are glycoproteins that are negative regulators of the Wnt pathway.1 SFRP1 is strongly expressed throughout embryonic development in different vertebrate species.2 It regulates cell proliferation, differentiation and apoptosis and negatively regulates bone formation.3 SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer.4 SFRP 1 is also a candidate tumor suppressor gene for lung cancer.5 Protein DetailsPurity >97% by SDS Page and HPLC Endotoxin Level <0.1 EU/µg as determined by the LAL method State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Human sFRP-1 is Mr 35-40 kDa. Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient References & Citations1. Bodine, PV. et al. (2007) J Cell Biochem. 102: 1519 2. Bovolenta, P. et al. (2004) Mech Dev. 121: 687 3. Lian, JB. et al. (2008) J Cell Physiol. 217: 113 4. Dahl, E. et al. (2004) Int J Oncol. 25: 641 5. Sekido, Y. et al. (2005) Oncogene 24: 6323 IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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