Recombinant Rat IL-13 (113 a.a.)

Recombinant Rat IL-13 (113 a.a.)

Product No.: I-451

[product_table name="All Top" skus="I-451"]

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Alternate Names
ALRH, BHR1, MGC116786, P600, NC30
Product Type
Recombinant Protein
Expression Host
E. coli Cells
Species
Rat

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Product Size
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Background

Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Protein Details

Purity
>98% by SDS Page and HPLC
Endotoxin Level
<1.0 EU/µg
Biological Activity
The biological activity of Rat Interleukin-13, 113 a.a., is determined by by the dose-dependent proliferation of TF-1 cells. The expected ED<sub>50</sub> for this effect is 2 x 10<sup>5</sup> units/mg.
Amino Acid Sequence
TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSIVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH
Storage and Stability
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA

References & Citations

1. Wynn TA. et al. (2003) Annu Rev Immunol. 21: 425
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.