Rapid Recombinant Protein and Monoclonal Antibody Production

Small to medium scale option using CHO, HEK293, and E.coli transgene expression systems

Leinco Technologies offers a panel of services to scientists looking for recombinant protein and monoclonal antibody production at the highest purity. These are available for conducting early discovery and preclinical research. Preclinical research is an essential and initial step for understanding the complexity and mechanisms of disease. Furthermore, these studies allow scientists and clinicians to create models of disease states and reveal the biochemical and cellular processes responsible for the development of diseases. As the precursors and courses of action of the disease are discovered, preclinical research is directed toward investigating the safety and efficacy of treatment theories.
 
Our novel patent-pending mammalian transgene expression system has been developed for expediting the expression of recombinant proteins and monoclonal antibodies for use in early discovery research, preclinical trials or in vitro diagnostic procedures. This transgene expression system was developed to transfect mammalian cells such as Chinese Hamster Ovary (CHO) or HEK-293 cells with high efficiency during suspension cell culture in stirred tank bioreactors. In addition, Leinco utilizes a proprietary protein-free cell culture media formulation that is chemically defined animal origin free, as well as a serum-free based media called AlphaGrow™. The high efficiency of transfection contributes to high levels of protein expression achieved in Leinco Technologies’ transgene expression system.

Economic Decision

Leinco Technologies’ methods for expediting recombinant protein and monoclonal antibody production may be a good economic decision in the preclinical discovery phase. In fact, it eliminates the expense and time associated with developing a stable cell line before the characteristics of the antibody are fully known. This method allows for the evaluation of antibody panels before moving forward with the establishment of a stable cell line. Mammalian expression systems also produce high purity recombinant proteins and monoclonal antibodies. This allows glycosylation and highly biologically active proteins with no need for refolding.

Leinco’s services include: