Angiotensin-Converting Enzyme 2 (NT) Blocking Peptide

14 amino acids near the N-terminus of human ACE2.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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14 amino acids near the amino terminus of human ACE2.

Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].¹ ,or the conversion of angiotensin II to angiotensin 1-7.² ACE 2 has direct effects on cardiac function², and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.³ ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).⁴ ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).⁵

1. Acton S et al. (2000) Circ Res. 87: E1 2. Gamliel-Lazarovich A et al. (2007) Cardiovasc Res. 73: 463 3. Nabel EG et al. (2000) N Engl J Med. 347: 1795 4. Raizada MK et al. (2009) Am J Respir Crit Care Med. 5. Yuan Y et al. (2009) Tohoku J Exp Med. 217: 123