Recombinant Antibody Production Services
Using Leinco’s Proprietary HEK293 and CHO Transgene Expression Systems
Leinco Technologies offers a panel of services to scientists looking for recombinant monoclonal antibody production at the highest purity. These are available for conducting early discovery and preclinical research. Preclinical research is an essential and initial step for understanding the complexity and mechanisms of disease. Furthermore, these studies allow scientists and clinicians to create models of disease states and reveal the biochemical and cellular processes responsible for the development of diseases. As the precursors and courses of action of the disease are discovered, preclinical research is directed toward investigating the safety and efficacy of treatment theories.
Antibody Production Service Highlights
- Gene Synthesis – Client approved DNA sequencing of any length and complexity.
- Cloning – Cloning of variable domains of the heavy and light chains (VH & VL).
- Transgene Expression – A proprietary rapid platform for expressing antibodies (mammalian and E. coli expression systems). Expression levels will be measured by ELISA and Protein A and Protein G recovery assays to determine optimal conditions.
- Optimization Experiments – R&D efforts to optimize cells and meet specific expression levels.
- Purification – Using Leinco’s proprietary robust multi-step recombinant antibody purification processes (Using Protein A or Protein G technology). Learn More
- Bio-Analytical Testing – Results in low endotoxin functional formulations for use in preclinical trials.
