mouse sitting on test tubes

In vivo grade antibodies have a variety of uses in biological research, from discovery of cell signaling pathways to manipulation of biological systems in animal models for pre-clinical studies. In vivo antibodies from Leinco Technologies have the highest purity standards in the industry, with low endotoxin levels, no detectable aggregates nor leachable protein A. These antibodies are produced in our cGMP and ISO 9001:2015 / ISO 13485:2015 certified facility and are available in custom concentrations and package sizes. In vivo PLATINUM antibodies are also suitable for animal injection as they are pathogen free as determined by the IDEXX Impact I PCR mouse pathogen profile.

Leinco Technologies offers a broad range of purified in vivo antibodies that can be utilized in flow cytometry, immunohistochemistry, spatial biology studies, and more. Compare and contrast in vivo GOLD™ vs. in vivo PLATINUM™ to see how they measure up to our quality standards! Antibodies are available in 1 mg, 5 mg, 25 mg, 50 mg and 100 mg sizes. Bulk sizes, custom concentrations and custom packaging are available on request.

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NEW in vivo PLATINUM™ Functional Grade

Antibody Clone Product
Anti-Mouse CD226 (DNAM-1) – Purified in vivo PLATINUM™ Functional Grade 480.1 D392
Anti-Mouse CD317 (Clone 927) – Purified in vivo PLATINUM™ Functional Grade 927 C792
Anti-Mouse CD96 – Purified in vivo PLATINUM™ Functional Grade 3.3.1 or 3.3 C780
Anti-Mouse IL-21R (Clone 4A9) – Purified in vivo PLATINUM™ Functional Grade 4A9 I-479
Anti-Ly49C (Clone 4LO3311) – Purified in vivo PLATINUM™ Functional Grade 4LO3311 L245
Anti-mouse CD16.2 (Clone 9E9) – Purified in vivo PLATINUM™ Functional Grade 9E9 C860
Anti-Chikungunya E1 Protein – Purified in vivo PLATINUM™ Functional Grade CHK-166 C479
Anti-Mouse CD183 (Clone CXCR3-173) – Purified in vivo PLATINUM™ Functional Grade CXCR3-173 C796
Anti-Mouse CD275 – Purified in vivo PLATINUM™ Functional Grade HK5.3 C2448
Anti-Rat Kappa Light Chain – Purified in vivo PLATINUM™ Functional Grade MAR 18.5 I-2026
Anti-Mouse CXCL9 (Clone MIG-2F5-5) – Purified in vivo PLATINUM™ Functional Grade MIG-2F5-5 C794
Anti-Mouse CD276 (Clone MJ18) – Purified in vivo PLATINUM™ Functional Grade MJ18 C3344
Anti-Mouse/Rat CD71 – Purified in vivo PLATINUM™ Functional Grade OX-26 C854
Anti-Mouse CD90.1 (Thy-1.1) (Clone OX-7) – Purified in vivo PLATINUM™ Functional Grade OX-7 C852
Anti-Mouse CD134 (Clone OX-86) – Purified in vivo PLATINUM™ Functional Grade OX-86 C856
Anti-Mouse CD200 (Clone OX-90) – Purified in vivo PLATINUM™ Functional Grade OX-90 C858
Anti-Mouse/Human CD49d (Clone PS/2) – Purified in vivo PLATINUM™ Functional Grade PS/2 C798
Anti-Mouse Galectin-9 (Clone RG9-1) – Purified in vivo PLATINUM™ Functional Grade RG9-1 C3342
Anti-Mouse CD27 (Clone RM27-3E5) – Purified in vivo PLATINUM™ Functional Grade RM27-3E5 C3232
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30) – Purified in vivo PLATINUM™ Functional Grade RMP1-30 C3440
Anti-Mouse 4-1BBL (Clone TKS-1) – Purified in vivo PLATINUM™ Functional Grade TKS-1 L320

NEW in vivo GOLD™ Functional Grade

Antibody Clone Product
Anti-Mouse CD226 (DNAM-1) – Purified in vivo GOLD™ Functional Grade 480.1 D391
Anti-Mouse CD317 (Clone 927) – Purified in vivo GOLD™ Functional Grade 927 C791
Anti-Human CXCR4 (Clone 12G5)(Sino Target) – Purified in vivo GOLD™ Functional Grade 12G5 C850
Anti-Mouse CD96 – Purified in vivo GOLD™ Functional Grade 3.3.1 or 3.3 C781
Anti-Mouse IL-21R (Clone 4A9) – Purified in vivo GOLD™ Functional Grade 4A9 I-478
Anti-Human TIGIT (Clone 4E1.2) – Purified in vivo GOLD™ Functional Grade 4E1.2 T810
Anti-Ly49C (Clone 4LO3311) – Purified in vivo GOLD™ Functional Grade 4LO3311 L244
Anti-Human CD151 – Purified in vivo GOLD™ Functional Grade 50-6 C2039
Anti-mouse CD16.2 (Clone 9E9) – Purified in vivo GOLD™ Functional Grade 9E9 C859
Anti-Mouse MHC Class I (H-2Kb) (Clone AF6-88.5) – Purified in vivo GOLDTM Functional Grade AF6-88.5 H1686
Anti-Chikungunya E1 Protein – Purified in vivo GOLD™ Functional Grade CHK-166 C468
Anti-Mouse CD183 (Clone CXCR3-173) – Purified in vivo GOLD™ Functional Grade CXCR3-173 C795
Anti-Human/Mouse integrin β7 (Clone FIB21) – Purified in vivo GOLD™ Functional Grade FIB21 F118
Anti-Mouse CD70 (Clone FR70) – Purified in vivo GOLD™ Functional Grade FR70 C2402
Anti-Mouse CD275 – Purified in vivo GOLD™ Functional Grade HK5.3 C2369
Anti-Rat Kappa Light Chain – Purified in vivo GOLD™ Functional Grade MAR 18.5 I-2027
Anti-Mouse CXCL9 (Clone MIG-2F5-5) – Purified in vivo GOLD™ Functional Grade MIG-2F5-5 C793
Anti-Mouse CD276 (Clone MJ18) – Purified in vivo GOLD™ Functional Grade MJ18 C3346
Anti-Mouse/Rat CD71 – Purified in vivo GOLD™ Functional Grade OX-26 C853
Anti-Mouse CD90.1 (Thy-1.1) (Clone OX-7) – Purified in vivo GOLD™ Functional Grade OX-7 C851
Anti-Mouse CD134 (Clone OX-86) – Purified in vivo GOLD™ Functional Grade OX-86 C855
Anti-Mouse CD200 (Clone OX-90) – Purified in vivo GOLD™ Functional Grade OX-90 C857
Anti-Mouse/Human CD49d (Clone PS/2) – Purified in vivo GOLD™ Functional Grade PS/2 C797
Anti-Mouse Galectin-9 (Clone RG9-1) – Purified in vivo GOLD™ Functional Grade RG9-1 C3340
Anti-Mouse CD27 (Clone RM27-3E5) – Purified in vivo GOLD™ Functional Grade RM27-3E5 C3230
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30) – Purified in vivo GOLD™ Functional Grade RMP1-30 C3442
Anti-mouse 4-1BBL (Clone TKS-1) – Purified in vivo GOLD™ Functional Grade TKS-1 L322

NEW Purified

Antibody Clone Product
Anti-Human CD151 – Purified
50-6 C2038
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30)- Purified RMP1-30 C3444

NEW Biotin

Antibody Clone Product
Anti-Mouse CD70 – Biotin FR70 C2404
Anti-Mouse CD275 (B7-H2) – Biotin HK5.3 C2371
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30) – Biotin RMP1-30 C3446
Anti-mouse 4-1BBL (Clone TKS-1) – Biotin TKS-1 L324

NEW PE

Antibody Clone Product
Anti-Human CD151 – PE
50-6 C2043
Anti-Mouse CD70 – PE FR70 C2406
Anti-Mouse CD275 (B7-H2) – PE HK5.3 C2373
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30) – PE RMP1-30 C3448
 Anti-mouse 4-1BBL (Clone TKS-1) – PE TKS-1 L326

NEW APC

Antibody Clone Product
Anti-Human CD151 – APC 50-6 C2042
Anti-Mouse CD70 – APC FR70 C2405
Coming Soon Anti-Mouse PD-1 (Clone RMP1-30) – APC
RMP1-30 C3450

GOLD™ vs. PLATINUM™ in vivo Antibody Quality Standards

Specifications gold in vivo antibody
platinum in vivo antibody
Binding validation determined by
WB, FC or ELISA
Yes Yes
Endotoxin level determined by
the LAL method
≤ 1.0 EU/mg ≤ 0.5 EU/mg
Antibody aggregation screening by analytical SEC ≥ 95% monomer ≥ 98% monomer
Purity by SDS PAGE ≥ 95% ≥ 98%
Formulation for in vivo use No preservatives
No stabilizers
No carrier protein
Sterile PBS pH 7.2 – No K+ or Ca2+
Concentration: > 5mg/mL
No preservatives
No stabilizers
No carrier protein
Sterile PBS pH 7.2 – No K+ or Ca2+
Concentration: > 5mg/mL
Murine pathogen screening Not applicable, see PLATINUM functional grade antibodies Pathogen tested (IMPACT1) (see table)
Applications In vivo functional studies and may be used for WB, FC, IF or IHC
Product preparation Functional grade preclinical antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• 1 month, 2 to 8 °C under sterile conditions, as supplied.
• 12 months, -70 °C under sterile conditions.

IDEXX IMPACT I (PCR-based) Mouse Pathogen Profile for Purified In vivo PLATINUM™ Grade Antibodies

Mycoplasma sp. Mouse adenovirus 1 (MAV1) Lactate dehydrogenase-elevating virus (LDEV)
Mycoplasma pulmonis Mouse adenovirus 2 (MAV2) Mouse kidney parvovirus (MKPV)
Sendai virus Murine norovirus (MNV) Hantaan Virus
Mouse hepatitis virus (MHV) Reovirus 3 (REO3) Mouse cytomegalovirus (mCMV)
Pneumonia virus of mice (PVM) Mouse rotavirus (EDIM) K virus
Minute virus of mice (MVM) Ectromelia virus Mouse thymic virus (MTV)
Mouse parvovirus (MPV) Polyomavirus Corynebacterium bovis
Theiler’s murine encephalomyelitis (TMEV) Lymphocytic choriomeningitis virus (LCMV) Corynebacterium sp.

Bioanalytical Data

Leinco in vivo antibodies

Figure 1. Quality control of in vivo antibodies: RMP1-14

In vivo antibodies from Leinco Technologies are subjected to extensive QC to ensure high reproducibility between lots. The example in Figure 1 shows the results for different lots of RMP1-14 antibody, directed against PD-1. The lots have consistently high purity as indicated by non-reducing and reducing SDS-PAGE (Fig. 1A and 1B, resp.). Analysis by size exclusion chromatography gave superimposing chromatograms for all nine lots, with overlapping retention times and minimal baseline noise (Fig. 1C). Endotoxin data for eight lots indicated that all lots were below the specification of ≤ 0.5 EU/mg as determined by the limulus amebocyte lysate (LAL) method (Fig. 1D).

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