What is an Immune Checkpoint?

A key function of the immune system is the ability to differentiate between normal and abnormal cells. When abnormal cells can be identified, the immune system destroys them while leaving normal cells intact. Immune checkpoint markers are responsible for this identification process. They are cell surface proteins on T-cells that can bind homologous receptor proteins on other cells, such as an antigen-presenting cell (APC). Activation of the immune checkpoint pathways results in either immune suppression or stimulation and plays a vital role in regulating the function of the immune system.

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Tumor cells adapt by learning to exploit checkpoint mechanisms to escape cell death by presenting cell surface proteins that are recognized as normal, even though the cell is abnormal and should be eliminated by the immune system. Antibodies and other drugs have been developed to modulate these immune checkpoints and allow for the restoration of anti-tumor activity by the immune system.

Leinco offers a wide range of the highest quality immune checkpoint modulating antibodies for use in mouse models.

Target Clone Prod. No.
TREM2 178 (LALAPG) mAbMods - T721
PD-1 (CD279) RMP1-14 mAbMods - P505
mAbMods (LALA-PG) - P504
mAbMods (D265A) - P503
29F.1A12 GOLD - P377
PLATINUM - P378
PD-L1 (B7-H1) 10F.9G2 GOLD - P363
PLATINUM - P371
PD-L2 (B7-DC) TY25 GOLD - C2292
PLATINUM - C9222
CTLA-4 9D9 GOLD - C2855
PLATINUM - C2856
UC10-4F10-11 GOLD - C2860
PLATINUM - C2444
9H10 GOLD - C1614
PLATINUM - C2841
LAG-3 C9B7W GOLD - L306
PLATINUM - C2852
4-1BB (CD137) 3H3 GOLD - C2830
PLATINUM - C2835
4-1BBL (CD137L) TKS-1 GOLD - L322
PLATINUM - L320
CD40 FGK4.5 GOLD - C2825
PLATINUM - F1195
CD40L (CD154) MR-1 GOLD - C2357
OX40 (CD134) OX-86 GOLD - C855
PLATINUM - C856
OX40L (CD134L) RM134L GOLD - C2336
CD28 37.51 GOLD - C379
PLATINUM - C1658
D665 COMING SOON!
CD80 (B7-1) 10A1 GOLD - C2045
PLATINUM - C2390
CD86 (B7-2) GL-1 GOLD - C2158
PLATINUM - C6158
CD276 (B7-H3) MJ18 GOLD - C3346
PLATINUM - C3344
TIM-1 (CD365) RMT1-10 COMING SOON!
TIM-3 (CD366) RMT3-23 GOLD - T700
PLATINUM - T720
B8.2C12 COMING SOON!
Galectin-9 RG9-1 GOLD - C3340
PLATINUM - C3342
ICOS 7E.17G9 GOLD - C2258
PLATINUM - C2851
ICOSL (CD275) HK5.3 GOLD - C2369
PLATINUM - C2448
CD27 RM27-3E5 GOLD - C3230
PLATINUM - C3232
CD70 FR70 GOLD - C2402
TIGIT 1G9 GOLD - T735
PLATINUM - T736