Anti-Mouse PD-L1 – Purified In vivo GOLD™ Functional Grade

Pricing & Details

Clone
10F.9G2
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
B7-H1, CD274
Isotype
Rat
IgG2b κ
Prod No.
Size
Price
Avail.
Qty
Add to cart
P363-0.5 mg
0.5 mg
$98.00
In stock
P363-1.0 mg
1.0 mg
$175.00
In stock
P363-5.0 mg
5.0 mg
$300.00
In stock
P363-25 mg
25 mg
$750.00
In stock
P363-100 mg
100 mg
$1,700.00
In stock

Antibody Details

Reactivity Species
Mouse
Host Species
Rat
Immunogen
UnKnown
Product Concentration
1.0 - 5.0 mg/ml
Formulation
This antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Handling
This Low Endotoxin Functional Formulation antibody is stable when stored at 2-8°C. Do not freeze.

Description

Specificity
Clone 10F.9G2 recognizes an epitope on mouse PD-L1.
Antigen Distribution
PD-L1 is present on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes.
Background
PD-1 is a 50-55 kD member of the B7 Ig superfamily. PD-1 is also a member of the extended CD28/CTLA-4 family of T cell regulators and is suspected to play a role in lymphocyte clonal selection and peripheral tolerance. The ligands of PD-1 are PD-L1 and PD-L2, and are also members of the B7 Ig superfamily. PD-1 and its ligands negatively regulate immune responses. PD-L1, or B7-Homolog 1, is a 40 kD type I transmembrane protein that has been reported to costimulate T cell growth and cytokine production. The interaction of PD-1 with its ligand PD-L1 is critical in the inhibition of T cell responses that include T cell proliferation and cytokine production. PD-L1 has increased expression in several cancers. Inhibition of the interaction between PD-1 and PD-L1 can serve as an immune checkpoint blockade by improving T-cell responses In vitro and mediating preclinical antitumor activity. Within the field of checkpoint inhibition, combination therapy using anti-PD1 in conjunction with anti-CTLA4 has significant therapeutic potential for tumor treatments. PD-L2 is a 25 kD type I transmembrane ligand of PD-1. Via PD-1, PD-L2 can serve as a coinhibitor of T cell functions. Regulation of T cell responses, including enhanced T cell proliferation and cytokine production, can result from mAbs that block the PD-L2 and PD-1 interaction.

Antigen Details

Protein Family
PD-L1
Ligand/Receptor
PD-1 (PDCD1)
NCBI Gene Bank ID
Flow Cytometry
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.