High-Purity Isoform-Specific Antibodies & Recombinant Proteins

Unlock the complexities of lipid metabolism, cardiovascular health, and Alzheimer’s disease pathology. Leinco Technologies offers a premier portfolio of Apolipoprotein E (ApoE) research tools engineered to accelerate your discovery timeline. Our specialized selection features high-purity recombinant human ApoE proteins (including the distinct ApoE2, ApoE3, and ApoE4 isoforms), robust mouse ApoE proteins, and highly targeted anti-ApoE antibodies.

Comprehensive Human ApoE Antibody Portfolio

Our antibody collection is designed to meet the demands of diverse platforms, from high-throughput ELISA to sensitive tissue imaging.

ApoE2

The protective isoform that is essential for studying lipid clearing and cardiovascular risk.

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ApoE3

The physiological standard that is used as a baseline for nearly all Alzheimer’s comparative studies

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ApoE4

The primary genetic risk factor for late-onset Alzheimer’s that is optimized for studies on beta aggregation.

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Mouse ApoE Antibodies and Proteins

Unlike human ApoE—which expresses three major alleles (the protective ε2, the neutral ε3, and the Alzheimer’s-linked ε4) — mouse ApoE expression is naturally limited to a single allele. Explore our complete portfolio of high-purity human variants and mouse APOE proteins to fuel your comparative neurobiology studies.

Recombinant ApoE Antibodies and Proteins

We offer high-purity, biologically active isoforms produced in diverse expression systems to ensure correct folding and post-translational modifications.

Product Category Features Applications
Recombinant ApoE Proteins Human ApoE2, ApoE3, and ApoE4 isoforms. In vivo infusions, cell-based assays, and lipid transport studies.
ApoE Antibodies Monoclonal and polyclonal options, including In Vivo Functional Grade. Western blotting, IHC, ELISA, and functional neutralization.
Custom ApoE Mutants Specialized production of rare variants like the Christchurch (R136S) mutation. Research into Alzheimer’s resilience and genetic protective factors.

We provide human recombinant antibodies and proteins expressed in both HEK293 cells (for native glycosylation and folding) and E. coli (for high-yield screening).

The Leinco Technical Advantage

  • Ultra-Low Endotoxin (<1.0 EU/µg): Minimizes non-specific inflammatory activation in cell-based assays.
  • Isoform Specificity: Verified via functional ELISA and Western Blot against a panel of recombinant isoforms.
  • No Carrier Protein: Formulated carrier-free to prevent interference in mass spectrometry and sensitive proteomics.
  • Validated Binding: All isoforms are tested for functional binding to the VLDL Receptor (VLDLR).
  • Quality Assurance: Manufactured to high standards within our ISO9001 certified environment, which provides a seamless transition for clients moving from R&D to clinical trials or diagnostic kit manufacturing.

Applications in Neurodegeneration:

Leinco’s ApoE reagents are the foundational tools for protocols exploring:

  • Amyloid-β Dynamics: Investigate how specific isoforms influence amyloid-β clearance and plaque formation.
  • Lipid Transport: Analyze the efficiency of cholesterol redistribution in the CNS and periphery.
  • Blood-Brain Barrier Studies: Tools for mapping the differential transport of ApoE isoforms across the BBB.