In vivo Cell Specific Depletion – T Cell, B Cell, NK Cells, and More

Leinco Technologies offers monoclonal antibodies to mouse cell specific surface proteins and cytokines for In vivo cell specific depletion studies.  Depletion can occur naturally (i.e. in HIV) or be induced for treatment purposes. Therefore, it is a useful tool in therapeutic, immunotherapy and diagnostic research. It is common practice for researchers to use antibodies to remove a specific cell type to infer its function and mouse cell depletion In vivo experiments are used to establish the role of specific cell types in a variety of immunological processes. As an example, In vivo T cell depletion experiments using a combination of anti-CD4 (Clone GK1.5) and anti-CD8 (Clone 2.43 or 53-5.8) antibodies are efficient and produce less deleterious effects on other blood cell populations compared to using CD3 depletion antibodies (Like clone 145-2C11 or 17A2) . Many of these antibodies have been developed by academic and government labs all over the world and have been reported and referenced for use in In vivo studies to deplete a specific cell type (See the List below organized by clone and cell type for depletion). Check out each clones datasheet for specific literature references and information on dosage and product use.

Leinco’s Cell-Specific Depletion Antibodies

Cell Type

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco T Cells

Cell Type

T Cells

Gold Catalog #

Platinum Catalog #

Leinco B Cells

Cell Type

B Cells

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco CD8+ T Cells

Cell Type

CD8+ T Cells

Gold Catalog #

Platinum Catalog #

Leinco CD4+ T Cells

Cell Type

CD4+ T Cells

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco Treg Cells

Cell Type

Treg Cells

Clone

Gold Catalog #

Platinum Catalog #

Leinco γδ T Cells

Cell Type

γδ T Cells

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco NK Cells

Cell Type

NK Cells

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco ICLs

Cell Type

ICLs

Clone

Gold Catalog #

Platinum Catalog #

Leinco Monocytes

Cell Type

Monocytes

Clone

Gold Catalog #

Platinum Catalog #

Leinco Macrophages

Cell Type

Macrophages

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco Neutrophils

Cell Type

Neutrophils

Target

Clone

Gold Catalog #

Platinum Catalog #

Leinco Eosinophils

Cell Type

Eosinophils

Target

Clone

Gold Catalog #

Platinum Catalog #