Anti-PD-1 Antibodies in vivo

Programmed cell death protein 1, commonly abbreviated as PD-1, is an inhibitory receptor expressed on some tumor cells, which reduces T-cell activity. Monoclonal Anti-PD-1 antibodies block the PD-1 receptor so the T cells are no longer inhibited, activating the immune response against the tumor.

Leinco Technologies offers three (3) unique anti-PD-1 monoclonal antibodies: 29F.1A12, RMP1-14, 384-35 (fully murinized). All PD-1 clones are used to block PD-1 signaling in vivo in mouse tumor models. Clone 384-35 is part of a new class of mouse anti-mouse antibodies that significantly increases survival past 100 days compared to RMP1-14 and shows tumor volume more than 2.5 fold smaller compared to RMP1-14. The available clones all have extensive publication records to support them. Leinco’s anti-mouse PD-1 antibodies are available in both in vivo GOLD™ and in vivo PLATINUM formats.

Which PD-1 Clone Is Best For My Research?

While all of Leinco’s PD-1 antibodies bind to PD-1 and block the signaling in vivo., here may be one clone that is better suited to your specific mouse model and research needs. Each antibody was created by different researchers at different times, however, they were all created using standard hybridoma technology.