Anti-Mouse CTLA-4 – Purified In vivo PLATINUM™ Functional Grade

Pricing & Details

Clone
9D9
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype
Mouse
IgG2b
Prod No.
Size
Price
Avail.
Qty
Add to cart
C2856-1.0 mg
1.0 mg
$198.00
In stock
C2856-5.0 mg
5.0 mg
$355.00
In stock
C2856-25 mg
25 mg
$995.00
In stock
C2856-50 mg
50 mg
$1,550.00
In stock
C2856-100 mg
100 mg
$2,220.00
In stock

Data

Antibody Details

Reactivity Species
Mouse
Host Species
Mouse
Immunogen
Not Available
Product Concentration
≥ 2.0 mg/ml
Formulation
This Low Endotoxin Functional Formulation, PLATINUM antibody is formulated in PBS pH 7.2 - 7.4 with no preservatives or carrier proteins added.
Product Preparation
Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Pathogen Testing
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM™ antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Description

Specificity
Clone 9D9 recognizes an epitope on mouse CTLA-4.
Antigen Distribution
CTLA-4 is expressed on activated T and B lymphocytes.
Background
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Antigen Details

Protein Family
CTLA-4
Ligand/Receptor
CD80 (B7.1), CD86 (B7.2)
Function
Negative regulator of T cell activation
NCBI Gene Bank ID
General Western Blot Protocol

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.