Matched Isotype Control
≥ 2.0 mg/ml
This Low Endotoxin Functional Formulation, PLATINUM antibody is formulated in PBS pH 7.2 - 7.4 with no preservatives or carrier proteins added.
Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM™ antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Clone 9D9 recognizes an epitope on mouse CTLA-4.
CTLA-4 is expressed on activated T and B lymphocytes.
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
CD80 (B7.1), CD86 (B7.2)
Negative regulator of T cell activation
NCBI Gene Bank ID
Products are for research use only. Not for use in diagnostic or therapeutic procedures.