Anti-Mouse CTLA-4 (Clone 9H10) – Purified in vivo GOLD™ Functional Grade

Pricing & Details

Product No.C1614
Clone
9H10
Protein
CTLA-4
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype
Syrian Hamster
IgG
Applications
B
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1614-1.0 mg
1.0 mg
$98.00
In stock
Max:
Min: 1
Step: 1
C1614-5.0 mg
5.0 mg
$325.00
In stock
Max:
Min: 1
Step: 1
C1614-25 mg
25 mg
$875.00
In stock
Max:
Min: 1
Step: 1
C1614-50 mg
50 mg
$1,450.00
In stock
Max:
Min: 1
Step: 1
C1614-100 mg
100 mg
$2,125.00
In stock
Max:
Min: 1
Step: 1

Data

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Syrian Hamster
Immunogen
Mouse CTLA-4-human IgG1 fusion protein
Product Concentration
≥ 5.0 mg/ml
Endotoxin Level
≤ 1.0 EU/mg as determined by the LAL method
Purity
≥95% monomer by analytical SEC
>95% by SDS Page
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Product Preparation
Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 9H10 recognizes an epitope on mouse CTLA-4.
Antigen Distribution
CTLA-4 is expressed on activated T and B lymphocytes.
Background
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Antigen Details

Protein
Ligand/Receptor
CD80 (B7-1), CD86 (B7-2)
Function
Negative regulator of T cell activation
PubMed
NCBI Gene Bank ID
Research Area
Immunology

References & Citations

1.) Wurster S. et al. (2020) The Journal of Infectious Diseases 222(6):1989–994 Journal Link
General Western Blot Protocol