Anti-Mouse CD152 (CTLA-4) [Clone 9H10] — Alexa Fluor® 488
Anti-Mouse CD152 (CTLA-4) [Clone 9H10] — Alexa Fluor® 488
Product No.: C1748AF
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Clone 9H10 Target CTLA-4 Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56 Isotype Syrian Hamster IgG Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Syrian Hamster Immunogen Purified Recombinant Mouse CTLA-4 (>98%) Product Concentration 0.2 mg/ml Formulation This Alexa Fluor® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Alexa Fluor® is a trademark of Life Technologies Corporation. State of Matter Alexa Fluor® 488 Storage and Handling This Alexa Fluor® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Excitation Laser Blue Laser (488 nm) Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 9H10 recognizes an epitope on mouse CTLA-4. Background CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity. Antigen Distribution CTLA-4 is expressed on activated T and B lymphocytes. Ligand/Receptor CD80 (B7-1), CD86 (B7-2) Function Negative regulator of T cell activation PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & CitationsTechnical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
