Specificity:

Rabbit Anti-Human β-Actin recognizes an epitope near the amino-terminus of human, mouse and rat β-Actin. This polyclonal antibody was purified using affinity chromatography.

Background:

Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism (reviewed in 1). The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging (2). β-actin is one of six different actin isoforms which have been identified. Like GAPDH, β-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Known Species Cross Reactivity: Ms+, Hu+, Rt+