Specificity:

Mouse Anti-Human Follicle Stimulating Hormone Beta (FSH-β) (Clone 181) recognizes Human Follicle Stimulating Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:

Follicle-stimulating hormone (FSH) is a heterodimeric glycoprotein and is composed of alpha and beta subunits. Alpha subunit is common to FSH and LH, while a unique beta subunit determines the biological specificity of each hormone. The synthesis of beta subunit is the primary rate-limiting step in the synthesis of each hormone.¹ Human mutations in the FSH beta gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited.²