Purified Recombinant Human FSH-β (>98%)
This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.
Storage and Handling
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Paired with Leinco Prod. No. F103, Clone No. 176: FSH 100%, BhCG < 1%, LH < 4%, ihCG *, TSH < 1% * 3,000 mIU/ml hCG causes 4.5% decrease in observed FSH. At higher concentrations of hCG, observed FSH reduced to zero. Paired with Leinco Prod. No. C102, Clone No.151: FSH 100%, BhCG < 1%, ihCG **, FSH < 1%, TSH < 1% **At high concentrations of hCG, observed FSH reduced to zero.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Mouse Anti-Human Follicle Stimulating Hormone Beta (FSH-β) (Clone 181) recognizes Human Follicle Stimulating Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Follicle-stimulating hormone (FSH) is a heterodimeric glycoprotein and is composed of alpha and beta subunits. Alpha subunit is common to FSH and LH, while a unique beta subunit determines the biological specificity of each hormone. The synthesis of beta subunit is the primary rate-limiting step in the synthesis of each hormone.1 Human mutations in the FSH beta gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited.2
References & Citations
1. Ryu KZ et al. (2000) J Korean Soc Endocrinol. 15: 179 2. Sluss Patrick et al. (2002) J clin endocrin and metabolism 87: 3702
Products are for research use only. Not for use in diagnostic or therapeutic procedures.