Anti-Human Follicle Stimulating Hormone Beta – Purified

Purified Recombinant Human FSH-β (>98%)

This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.

For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Paired with Leinco Prod. No. F103, Clone No. 176: FSH 100%, BhCG < 1%, LH < 4%, ihCG *, TSH < 1% * 3,000 mIU/ml hCG causes 4.5% decrease in observed FSH. At higher concentrations of hCG, observed FSH reduced to zero. Paired with Leinco Prod. No. C102, Clone No.151: FSH 100%, BhCG < 1%, ihCG **, FSH < 1%, TSH < 1% **At high concentrations of hCG, observed FSH reduced to zero.

Next Day Ambient

Mouse Anti-Human Follicle Stimulating Hormone Beta (FSH-β) (Clone 181) recognizes Human Follicle Stimulating Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Follicle-stimulating hormone (FSH) is a heterodimeric glycoprotein and is composed of alpha and beta subunits. Alpha subunit is common to FSH and LH, while a unique beta subunit determines the biological specificity of each hormone. The synthesis of beta subunit is the primary rate-limiting step in the synthesis of each hormone.¹ Human mutations in the FSH beta gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited.²

1. Ryu KZ et al. (2000) J Korean Soc Endocrinol. 15: 179 2. Sluss Patrick et al. (2002) J clin endocrin and metabolism 87: 3702