Anti-Human Follicle Stimulating Hormone Beta – Purified

Anti-Human Follicle Stimulating Hormone Beta – Purified

Product No.: F102

[product_table name="All Top" skus="F102"]

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Clone
181
Target
FSH
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human FSH-β (>98%)
Product Concentration
1.0 mg/ml
Formulation
This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09% sodium azide.
Storage and Handling
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Cross Reactivity
Paired with Leinco Prod. No. F103, Clone No. 176: FSH 100%, BhCG < 1%, LH < 4%, ihCG *, TSH < 1% * 3,000 mIU/ml hCG causes 4.5% decrease in observed FSH. At higher concentrations of hCG, observed FSH reduced to zero. Paired with Leinco Prod. No. C102, Clone No.151: FSH 100%, BhCG < 1%, ihCG **, FSH < 1%, TSH < 1% **At high concentrations of hCG, observed FSH reduced to zero.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human Follicle Stimulating Hormone Beta (FSH-β) (Clone 181) recognizes Human Follicle Stimulating Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Follicle-stimulating hormone (FSH) is a heterodimeric glycoprotein and is composed of alpha and beta subunits. Alpha subunit is common to FSH and LH, while a unique beta subunit determines the biological specificity of each hormone. The synthesis of beta subunit is the primary rate-limiting step in the synthesis of each hormone.1 Human mutations in the FSH beta gene have been shown to produce complete deficiency states in which pubertal development and reproductive capacity are inhibited.2

Antigen Details

PubMed
Research Area
Hormones
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IVD Raw Material

References & Citations

1. Ryu KZ et al. (2000) J Korean Soc Endocrinol. 15: 179 2. Sluss Patrick et al. (2002) J clin endocrin and metabolism 87: 3702

Formats Available

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.