Anti-Human Apoptosis Related Protein (NT) (ARTS)

PN:A192

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human ARTS recognizes an epitope near the N-terminus of Human ARTS. This polyclonal antibody was purified using affinity chromatography.

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

1. Larisch, S. et al. (2000) Nat Cell Biol 2(12):915
2. Depraetere, V. (2000) Nat Cell Biol. 2(12):E219
3. Paavola, P. et al. (1999) Genomics 55(1):122
4. Zieger, B. et al. (2000) Gene 261(2):197