This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human ARTS recognizes an epitope near the N-terminus of Human ARTS. This polyclonal antibody was purified using affinity chromatography.
Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
References & Citations
1. Larisch, S. et al. (2000) Nat Cell Biol 2(12):915
2. Depraetere, V. (2000) Nat Cell Biol. 2(12):E219
3. Paavola, P. et al. (1999) Genomics 55(1):122
4. Zieger, B. et al. (2000) Gene 261(2):197
Products are for research use only. Not for use in diagnostic or therapeutic procedures.