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Adiponectin (NT) Blocking Peptide
(ADIPOQ, ACDC, ACRP30, APM-1, APM1, GBP28)
Blocking Peptide
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Size


Prod. No.:A278
Conc.:0.2 mg/ml
Pkg. Size:50 µg
Storage:-20°C Detailed storage instructions below.
Description
Background:
Adiponectin, also known as Acrp30, is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. It is induced during adipocyte differentiation, and its secretion is stimulated by insulin. It promotes adipocyte differentiation, fatty acid catabolism, and insulin sensitivity and is negatively correlated with obesity, type 2 diabetes, and atherogenesis. In this context, Adiponectin is an anti-inflammatory agent, but it exerts pro-inflammatory effects in nonmetabolic disorders such as rheumatoid arthritis and inflammatory bowel disease. Adiponectin interacts with the receptors AdipoR1 and AdipoR2, calreticulin, and Cadherin-13/T-Cadherin, as well as with several growth factors. Mature human Adiponectin shares 83% and 85% amino acid (aa) sequence identity with mouse and rat Adiponectin, respectively. The glycosylation of four hydroxylated lysine residues in the collagenous domain is required for the intracellular formation of HMW complexes. The various multimeric forms of Adiponectin exhibit distinct tissue specific and gender specific profiles and activities.

Adiponectin peptide is applicable as a control peptide for blocking antibody binding in Western blotting.

Amino Acid Location
15 amino acids near the amino terminus of human adiponectin.
Formulation
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Storage and Stability
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
References
1. Yamagata K, Sanders LK, Kaufman WE, et al. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 1994; 269:16333-9.

2. Yee WM and Worley PF. Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals. Mol. Cell. Biol. 1997; 17:921-3.

3. Inoki K, Li Y, Xu T, et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003; 17:1829-34.

4. Stocker H, Radimerski T, Schindelholz B, et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 2003; 5:559-65.
Related Products
Anti-Human Adiponectin (NT) (Leinco Prod. No.: A269)
Adiponectin (CT) Blocking Peptide (Leinco Prod. No.: A277)
Recombinant Human Adiponectin (Leinco Prod. No.: A321)
Anti-Mouse Adiponectin Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: A393)
Anti-human Adiponectin (Leinco Prod. No.: A369)
Anti-Human Adiponectin (CT) (Leinco Prod. No.: A268)
Anti-Mouse Adiponectin (Antigen Aff. Pur.) (Leinco Prod. No.: A355)
Recombinant Mouse Adiponectin (Leinco Prod. No.: A411)
Recombinant Human gAcrp30 (Leinco Prod. No.: A222)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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