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Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2)
Purified No Carrier Protein
(ACEH)
Polyclonal Antibody
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Prod. No.:A315
Host:Rabbit
Conc.:0.5 mg/ml
Pkg. Size:0.1 mg, 0.5 mg, 1 mg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2) recognizes an epitope in the intermediate domain of Human ACE2. This polyclonal antibody was purified using affinity chromatography.

Background:
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].1 ,or the conversion of angiotensin II to angiotensin 1-7.2 ACE 2 has direct effects on cardiac function2, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.3 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).4 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).5

Known Species Cross Reactivity: Hu+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Each investigator should determine their own optimal working dilution for specific applications.


Country of Origin
USA
References
1. Acton S et al. (2000) Circ Res. 87: E1
2. Gamliel-Lazarovich A et al. (2007) Cardiovasc Res. 73: 463
3. Nabel EG et al. (2000) N Engl J Med. 347: 1795
4. Raizada MK et al. (2009) Am J Respir Crit Care Med.
5. Yuan Y et al. (2009) Tohoku J Exp Med. 217: 123
Related Products
Angiotensin-Converting Enzyme 2 (Intermediate Domain - 2) Blocking Peptide (Leinco Prod. No.: A296)
Anti-Human Angiotensin-Converting Enzyme 2 (CT) (Leinco Prod. No.: A313)
Anti-Human Angiotensin-Converting Enzyme 2 (Intermediate Domain 1) (Leinco Prod. No.: A314)
Anti-Human Angiotensin-Converting Enzyme 2 (NT) (Leinco Prod. No.: A316)
Angiotensin-Converting Enzyme 2 (CT) Blocking Peptide (Leinco Prod. No.: A294)
Angiotensin-Converting Enzyme 2 (NT) Blocking Peptide (Leinco Prod. No.: A297)
Angiotensin-Converting Enzyme 2 (Intermediate Domain 1) Blocking Peptide (Leinco Prod. No.: A295)
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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