Anti-ACE2 (Intermediate Domain)
Pricing & Details
ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within amino acids 150 - 200 of ACE2.
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Applications and Recommended Usage?
Quality Tested by Leinco
WB ACE2 antibody can be used for the detection of ACE2 by Western blot at 1 μg/mL.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2) recognizes an epitope in the intermediate domain of Human ACE2. This polyclonal antibody was purified using affinity chromatography.
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin. ACE 2 has direct effects on cardiac function, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys. ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH). ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).
References & Citations
1. Acton, S. et al. (2000) Circ Res. 87: E1
2. Gamliel-Lazarovich, A. et al. (2007) Cardiovasc Res. 73: 463
3. Nabel, EG. et al. (2000) N Engl J Med. 347: 1795
4. Raizada, MK. et al. (2009) Am J Respir Crit Care Med. 179(11):1048-54.
5. Yuan, Y. et al. (2009) Tohoku J Exp Med. 217: 123
Products are for research use only. Not for use in diagnostic or therapeutic procedures.