Anti-ACE2 (CT)

Pricing & Details

Product No.A313
Protein
ACE2
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, SARS-CoV receptor, SARS-CoV-2 receptor
Isotype
Rabbit
IgG
Applications
ELISA
,
IF
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
A313-0.1 mg
0.1 mg
$375.00
In stock
Max:
Min: 1
Step: 1

Data

Antibody Details

Product Details

Reactivity Species
Human
Mouse
Rat
Host Species
Rabbit
Immunogen
Anti-ACE2 antibody was raised against a peptide corresponding to 18 amino acids near the carboxy terminus of human ACE2. The immunogen is located within the last 50 amino acids of ACE2.
Product Concentration
1.0 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Applications and Recommended Usage?
Quality Tested by Leinco
WB ACE2 antibody can be used for the detection of ACE2 by Western blot at 1 μg/mL.
ELISA
IF
IHC FFPE
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Angiotensin-Converting Enzyme 2 (ACE2) recognizes an epitope near the C-terminus of Human ACE2. This polyclonal antibody was purified using affinity chromatography.
Background
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin ,or the conversion of angiotensin II to angiotensin. ACE 2 has direct effects on cardiac function, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys. ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH). ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).

Antigen Details

Protein
PubMed
Research Area
COVID-19
.
Viral

References & Citations

1. Donoghue et al. (2000) Circ. Res. 87:1-9 2. Tipnis et al. J Biol. Chem. (2000);,275:33238-43. 3. Li et al. Nature (2003);426:450-4. 4. Lu et al. The Lancet 2020 (published online).
Elisa Sandwich Protocol
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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