Anti-Human Apoptosis Inhibitor of Macrophages (AIM) (NT) [A246] : Leinco Technologies, excellence in early discovery research

0 $0.00

Product Datasheet

www.leinco.com

excellence in early discovery research

Rabbit Anti-Human Apoptosis Inhibitor of Macrophages (AIM)

Purified No Carrier Protein

(API6, SP alpha, CD5L)

Polyclonal Antibody

Share |

Size

Add to Cart:

Prod. No.:	A246
Host:	Rabbit
Conc.:	0.5 mg/ml
Pkg. Size:	0.1 mg, 0.5 mg, 1 mg
Storage:	2-8°C Detailed storage instructions below.

Description

Specificity:

Rabbit Anti-Human Apoptosis Inhibitor of Macrophages (AIM) recognizes an epitope near the N-terminus of human and mouse AIM. This polyclonal antibody was purified using affinity chromatography.

Background:

Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.

Known Species Cross Reactivity: Ms+, Hu+

Immunogen

Apoptosis Inhibitor of Macrophages (NT) Blocking Peptide (Leinco Prod. No.: A258)

Blocking Peptide

Apoptosis Inhibitor of Macrophages (NT) Blocking Peptide (Leinco Prod. No.: A258)

Formulation

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Storage and Stability

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Reported Applications

Each investigator should determine their own optimal working dilution for specific applications.

Country of Origin

USA

References

1. Miyazaki T, Hirokami Y, Matsuhashi N, et al. Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J. Exp. Med. 1999; 189:413-22.

2. Biancone L, Bowen MA, Lim A, et al. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. J. Exp. Med. 1996; 184:811-9.

3. Haruta I, Kato Y, Hashimoto E, et al. Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytic function of macrophages. J. Biol. Chem. 2001; 276:22910-4

4. Kuwata K, Watanabe H, Jiang S-Y, et al. AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice. Am. J. Path. 2003; 162:837-47.