This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human Apoptosis Inhibitor of Macrophages (AIM) recognizes an epitope near the N-terminus of human and mouse AIM. This polyclonal antibody was purified using affinity chromatography.
Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.
References & Citations
1. Miyazaki, T. et al. (1999) J. Exp. Med. 189:413-22.
2. Biancone, L. et al. (1996) J. Exp. Med. 184 :811-9.
3. Haruta, I. et al. (2001) J. Biol. Chem. 276:22910-4
4. Kuwata, K. et al. (2003) Am. J. Path. 162:837-47.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.