Recombinant Mouse IL-11 Rα (aa 26-367)

Interleukin 11 receptor alpha (IL11RA) is a subunit of the interleukin 11 receptor that is expressed in hematopoietic and other organs.¹ IL11RA is a functional target in bone metastasis and is considered as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor.^2/sup>

Fc Fusion Protein

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Cys26

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-11 Rα is Mr 64.6 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 75-80 kDa.

65

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Begley, CG. et al. (1997) Blood 90: 2148
2. Pasqualini, R. et al. (2009) Cancer Res. 69: 1995