Anti-Human CTRP3 (Intermediate Domain)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:C1262 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828387 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human CTRP3 recognizes an epitope in the intermediate domain of Human and Mouse CTRP3. This polyclonal antibody was purified using affinity chromatography. Background Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7.2 Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues.3 An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene.4 Multiple isoforms of human CTRP3 have been reported. It has been suggested that CTRP3 may play a role in skeletal development. Antigen DetailsPubMed References & Citations1. Fantuzzi, G. (2005) J. Allergy Clin. Immunol. 115:911 2. Tsao, TS. et al. (2002) Euro. J. Pharmacol. 440:213 3. Wong, GW. et al. (2004) Proc. Natl. Acad. Sci. USA 101:10302 4. Shapiro, L. et al. (1998) Curr. Biol. 8:335 Technical Protocols |
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