Anti-Human IL-23 (CT)

PN:I-510

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Interleukin-23 (IL-23) recognizes an epitope near the C-terminus of Human and Mouse IL-23. This polyclonal antibody was purified using affinity chromatography.

Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-γ, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

1. Hunter, C. A. (2005) Nat. Rev. Immunol. 5:521 2. Oppmann, B. et al. (2000) Immunity 13:715 3. Sheibanie, A. F. et al. (2004) FASEB J. 18:1318 4. Pirhonen, J. et al. (2002) J. Immunol. 169:5673