Recombinant Human Dtk

Dtk belongs to a recently recognized subfamily of receptor tyrosine kinases that also includes Ufo (Axl/Ark) and Mer (Eyk). Ligands for Dtk and Ufo have been identified as protein S and the related molecule Gas6, respectively. Dtk is likely to be involved in the regulation of hematopoiesis, particularly during the embryonic stages of blood cell development. ¹ DTK is also abundantly expressed in adult kidney, testis, and ovary. ²

Fc Fusion Protein

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Ala41

Lyophilized

The predicted molecular weight of Recombinant Human Dtk is Mr 69 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100-110 kDa.

69

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Crosier, KE. et al. (1996) Exp Hematol 24:318
2. Crosier, PS. et al. (1994) Growth Factors 11:137