Recombinant Human FGF R1β (IIIb)
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BackgroundFibroblast growth factor receptor-1 beta (FGFR1- beta) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-beta is expressed in basal epithelial cells and smooth muscle cells.1 FGF R1β supports progression and chemoresistance in subsets of acute myeloid leukemias (AML).2 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity The biological activity of Human FGF R1β (IIIb) was determined by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblasts. The expected ED<sub>50</sub> is 1 - 3 ng/ml. Fusion Protein Tag Fc Fusion Protein Protein Accession No. Amino Acid Sequence Human FGF R1β (IIIb) (Arg22 - Lys221) - 47 aa IIIb Ig domain (His1 - Pro47) - Human FGF R1β (IIIb) (Ala269 - Glu285) - IEGRDMD - Human IgG1 (Pro100 - Lys330) N-terminal Sequence Analysis Arg22 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human FGF R1β (IIIb) is Mr 56 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa. Predicted Molecular Mass 56 Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Moscatelli, D. et al. (2007) Prostate 67: 115 2. Raffi, S. et al. (2006) Leukemia 20: 979 Technical Protocols IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
