Recombinant Human IL-13 Rα2
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BackgroundInterleukin 13 receptor alpha 2, also known as IL13RA2 and CD213A2, binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 serves as a dominant negative inhibitor or a decoy receptor for IL-13.1 IL-13Ralpha2 is a promising target for ovarian cancer therapy, and the soluble form of IL-13R may be a possible surrogate marker for disease monitoring.2 IL13RA2 signaling during prolonged inflammation is also an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis.3 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Fusion Protein Tag Fc Fusion Protein Protein Accession No. Amino Acid Sequence ctsssdtei kvnppqdfei vdpgylgyly lqwqpplsld hfkectveye lkyrnigset wktiitknlh ykdgfdlnkg ieakihtllp wqctngsevq sswaettywi spqgipetkv qdmdcvyynw qyllcswkpg igvlldtnyn lfywyegldh alqcvdyika dgqnigcrfp yleasdykdf yicvngssen kpirssyftf qlqnivkplp pvyltftres sceiklkwsi plgpiparcf dyeieiredd ttlvtatven etytlkttne trqlcfvvrs kvniycsddg iwsewsdkqc wegedlskkt lltdiegrmd pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgvevhn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg khhhhhh
State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human IL-13 Rα2 is Mr 64 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 75-95 kDa. Predicted Molecular Mass 65 Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Low, WC. et al. (2003) Neuro Oncol. 5: 179 2. Puri, RK. et al. (2006) Cancer 107: 1407 3. Kitani, A. et al. (2006) Nat Med. 12: 99 Technical ProtocolsIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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