Recombinant Human P-Cadherin

Cadherin 3, type 1, Placental-cadherin (P-cad), also known as CDH3 is a transmembrane protein involved in the cell-cell contact surface of basal keratinocytes and is homologous to E-cadherin.¹ P-cad is expressed in placenta, epithelia, the basal cell of the skin, playing an important role in the morphogenesis of epidermis and skin appendage. The expression of P-cad in epithelial tissues appears to identify cell populations with proliferative activity, and its expression decreases as cells differentiate.¹ P-cadherin, expressed in normal breast myoepithelial cells, has been reported in breast carcinomas, where it is associated with high-grade histological tumors and proliferation.²

Fc Fusion Protein

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Asp108

Lyophilized

The predicted molecular weight of Recombinant Human P-Cadherin is Mr 87.4 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 120-130 kDa.

87.4`

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Carinci, F. et al. (2005) BMC Cancer 5: 63
2. Jerónimo, C. et al. (2005) FEBS Journal 272