Recombinant Mouse BMPR-IA

Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor 1A (BMPR-1A), also known as activin receptor-like kinase (ALK)-3, is a monomeric glycoprotein and is a one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-β family cytokines.

Human and mouse BMPR-IA are highly conserved and share 98% sequence identity.

BMPRIA immunohistochemistry may be a promising new tool for the identification of enteric ganglion cells in the evaluation of patients with neurointestinal disorders.

Fc Fusion Protein

qnldsml hgtgmksdld qkkpengvtl apedtlpflk cycsghcpdd ainntcitng hcfaiieedd qgettltsgc mkyegsdfqc kdspkaqlrr tieccrtnlc nqylqptlpp vvigpffdgs iriegrmdpk scdkthtcpp cpapellggp svflfppkpk dtlmisrtpe vtcvvvdvsh edpevkfnwy vdgvevhnak tkpreeqyns tyrvvsvltv lhqdwlngke ykckvsnkal papiektisk akgqprepqv ytlppsrdel tknqvsltcl vkgfypsdia vewesngqpe nnykttppvl dsdgsfflys kltvdksrwq qgnvfscsvm healhnhytq kslslspgkh hhhhh

Gln24 predicted

Lyophilized

The predicted molecular weight of Recombinant Mouse BMPR-IA is Mr 41.5 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 55 kDa.

41.5

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Li, L. et al. (2011) Dev. Biol. 349:451.
2. Miura, S. et al. (2010) Dev. Biol. 341:246.