Anti-Human IL-27 (Intermediate Domain)

PN:I-512

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Interleukin-27 (IL-27) recognizes an epitope in the intermediate domain of Human and Mouse IL-27. This polyclonal antibody was purified using affinity chromatography.

Interleukin-27 (IL-27) is a novel IL-12 family member that plays a role in the early regulation of T helper cell 1 initiation, including induction of T-bet and IL-12 receptor beta 2 expression.¹ IL-27 is produced by antigen-presenting cells² and plays an important function in regulating the activity of B and T lymphocytes.3 IL27 may be a potential therapeutic agent against rheumatoid arthritis (RA) at the onset of the disease.⁴

1. Yoshimoto T et al. (2004) Cancer Res. 64: 1152 2. De Sauvage FJ et al. (2003) Proceedings of the National Acad of Sci of USA 100: 15047 3. Devergne O et al. (2006) J Immunol. 176: 5890 4. Liew FY et al. (2008) Ann Rheum Dis. 67: 1474