Anti-Human NALP1

PN:N170

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human NALP1 recognizes Human NALP1. This polyclonal antibody was purified using affinity chromatography.

NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.¹ It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.² Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.³ NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.⁴ Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.³

1. Tschopp, J. et al. (2003) Nat. Rev. Mol. Cell Biol. 4:95
2. Chu. ZL. et al. (2001) J. Biol. Chem. 276:9239
3. Hlaing, T. et al. (2001) J. Biol. Chem. 276:9230
4. Sanz, C. et al. (2004) Biochem. J. 384:281