Anti-Human NALP1

Pricing & Details

Product No.N157
Protein
NALP1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
CARD7, DEFCAP, NACHT Domain-Leucine-Rich-Repeat and PYD-Containing Protein 1
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N157-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
N157-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N170
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human NALP1 recognizes Human NALP1. This polyclonal antibody was purified using affinity chromatography.
Background
NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.1 It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.2 Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.3 NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.4 Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.3

Antigen Details

Protein
PubMed

References & Citations

1. Tschopp, J. et al. (2003) Nat. Rev. Mol. Cell Biol. 4:95
2. Chu. ZL. et al. (2001) J. Biol. Chem. 276:9239
3. Hlaing, T. et al. (2001) J. Biol. Chem. 276:9230
4. Sanz, C. et al. (2004) Biochem. J. 384:281
IHC
General Western Blot Protocol
Prod No.
Description
N170
N157
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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