Recombinant Human Erythropoietin Receptor

The erythropoietin receptor is a transmembrane protein belonging to the member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. EPO-R transmits signals important for both proliferation and differentiation along the erythroid lineage.¹ Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.

apppnl pdpkfeskaa llaargpeel lcfterledl vcfweeaasa gvgpgnysfs yqledepwkl crlhqaptar gavrfwcslp tadtssfvpl elrvtaasga pryhrvihin evvlldapvg lvarladesg hvvlrwlppp etpmtshiry evdvsagnga gsvqrveile grtecvlsnl rgrtrytfav rarmaepsfg gfwsawsepv slltpsdldp

Lyophilized

The predicted molecular weight of Recombinant Human Erythropoietin sR, Epo is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 32 kDa.

25

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Mathey-Prevot, B. et al. (1993) Proc Nathl Acad Sci USA. 90: 11351