Anti-Human Epo R – FITC
Anti-Human Epo R – FITC
Product No.: E302
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Clone 38409 Target Erythropoietin Receptor Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2b Applications FC |
Data
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Formulation This monoclonal antibody is conjugated to fluorescein and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative. Storage and Handling This Fluorescein (FITC) conjugate is stable for at least twelve months when stored at 2-8°C protected from light. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (488 nm) RRIDAB_2830074 Applications and Recommended Usage? Quality Tested by Leinco Flow Cytometry: This conjugate has been pre-diluted to use approximately 10 µl per test when staining cells for flow cytometry. A typical test sample constitutes approximately 50 µl of packed whole blood or 1 x 106 continuous passage or activated cell cultures that have been centrifuged at 500 X g for five minutes and resuspended in 200-400 µl of 1X PBS. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human Erythropoietin Receptor (Ero R) (Clone 38409) recognizes an epitope on Human Ero R. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background The erythropoietin receptor is a transmembrane protein belonging to the member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. EPO-R transmits signals important for both proliferation and differentiation along the erythroid lineage.1 Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Antigen DetailsPubMed NCBI Gene Bank ID UniProt.org Technical Protocols |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
