Recombinant Human IL-1Rrp2

Interleukin-1 receptor related protein 2 (IL-1Rrp2) is a receptor for IL-1F6 which is a proinflammatory member of IL-1 family. IL-1F8, and IL-1F9 also signal through IL-1Rrp2 and IL-1RAcP.¹ IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defense in the skin and the gastrointestinal (GI) tract including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8, indicating a possible role in rheumatoid arthritis (RA).²

Fc Fusion Protein

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Asp20

Lyophilized

The predicted molecular weight of Recombinant Human IL-1Rrp2 is Mr 62.8 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 80 kDa.

62.8

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Sims, JE. et al. (2004) J Biol Chem. 279: 13677
2. Taylor, JJ. et al. (2007) Clin Exp Immunol. 147: 217