Recombinant Rat IL-1Rrp2
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BackgroundInterleukin-1 receptor related protein 2 (IL-1Rrp2) is a receptor for IL-1F6 which is a proinflammatory member of IL-1 family. IL-1F8, and IL-1F9 also signal through IL-1Rrp2 and IL-1RAcP.1 IL-1F6, IL-1F8 and Il-1F9 are agonists and, along with their receptor IL-1Rrp2, are highly expressed in epithelial cells suggesting a role in immune defense in the skin and the gastrointestinal (GI) tract including the mouth. Synovial fibroblasts and articular chondrocytes also express IL-1Rrp2 and respond to IL-1F8, indicating a possible role in rheumatoid arthritis (RA).2 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Fusion Protein Tag Fc Fusion Protein Protein Accession No. Amino Acid Sequence gnctdvymh hemisegqpf pfnctyppvt ngavnltwhr tpskspisin rhvrihqdqs wilflplale dsgiyqcvik dahscyriai nltvfrkhwc dssneessin ssdeyqqwlp igksgsltch lyfpescvld sikwykgcee ikvskkfcpt gtkllvnnid vedsgsyacs arlthlgrif tvrnyiavnt kevgsggrip nitypknnsi evqlgstliv dcnitdtken tnlrcwrvnn tlvddyyndf kriqegietn lslrnhilyt vnitflevkm edyghpftch aavsaayiil krpapdfray diegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgk
N-terminal Sequence Analysis Gly22 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Rat IL-1Rrp2 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100 kDa. Predicted Molecular Mass 63 Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Sims, JE. et al. (2004) J Biol Chem. 279: 13677 2. Taylor, JJ. et al. (2007) Clin Exp Immunol. 147: 217 IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
