Anti-Human GDF-3 – Biotin
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen Purified Recombinant Human GDF-3 (>98%) Formulation This biotinylated antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added. Storage and Handling This lyophilized biotinylated polyclonal antibody should be stored desiccated at -20°C. The reconstituted conjugate is stable for at least one month when stored at 2 - 8°C. For long term storage aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid More Than One Freeze Thaw Cycle. Country of Origin USA Shipping Next Day Ambient RRIDAB_2830243 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human Growth and Differentiation Factor-3 (GDF-3) recognizes Human GDF-3. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research. Background Growth differentiation factor-3 (GDF3) also known as Vg-related gene 2 (Vgr-2), is a protein belonging to the transforming growth factor beta (TGF-β) superfamily.
It has high similarity to other TGF-β superfamily members called Vg1, BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.1 Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.2,3 GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.4 GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.5 Antigen DetailsReferences & Citations1. van den Eijnden-van Raaij A et al. (1998) Oncogene 16: 95
2. Brown C et al. (2006) Development 133: 319
3. Yu L et al. (2005) Neurosci Lett 389: 83
4. Brivanlou A et al. (2006) Cell Cycle 5: 1069
5. Brivanlou AH. et al. (2006) Developement 133: 209
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.