Anti-Human GDF-3

Anti-Human GDF-3

Product No.: G592

[product_table name="All Top" skus="G592"]

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Target
Growth Differentiation Factor 3
Product Type
Polyclonal Antibody
Alternate Names
Vgr-2, UNQ222/PRO248
Applications
ELISA Cap
,
ELISA Indirect
,
N
,
WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human GDF-3 (>98%)
Formulation
This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Storage and Handling
The lyophilized antibody should be stored desiccated at -20°C. The reconstituted antibody can be stored for at least six weeks at 4°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day USA Ambient $25
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Growth and Differentiation Factor-3 (GDF-3) recognizes Human GDF-3. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Background
Growth differentiation factor-3 (GDF3) also known as Vg-related gene 2 (Vgr-2), is a protein belonging to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members called Vg1, BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.1 Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.2,3
GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling.4 GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types.5

Antigen Details

References & Citations

1. van den Eijnden-van Raaij A et al. (1998) Oncogene 16: 95 2. Brown C et al. (2006) Development 133: 319 3. Yu L et al. (2005) Neurosci Lett 389: 83 4. Brivanlou A et al. (2006) Cell Cycle 5: 1069 5. Brivanlou AH. et al. (2006) Developement 133: 209
Elisa Sandwich Protocol
Indirect Elisa Protocol
N
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.