Anti-Mouse FGF-9

Anti-Mouse FGF-9

Product No.: F109

[product_table name="All Top" skus="F109"]

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Target
Fibroblast Growth Factor-9
Product Type
Polyclonal Antibody
Alternate Names
Growth Factor-9, GAF (Glia-Activating Factor), HBGF-9, HBFG-9, MGC119914, MGC119915
Applications
ELISA Indirect
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N
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WB

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rabbit
Immunogen
Purified Recombinant Mouse FGF-9 (>98%)
Formulation
This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added.
Storage and Handling
The lyophilized antibody should be stored desiccated at -20°C. The reconstituted antibody can be stored for at least six weeks at 4°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Mouse Fibroblast Growth Factor (FGF-9) recognizes Mouse FGF-9. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
Background
Fibroblast growth factor 9 (glia-activating factor), also known as FGF9 is a glycosylated neurotrophic polypeptide highly expressed in brain.1 It is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. FGF-9 has sequence similarity of approximately 30% to other members of the family of fibroblast growth factors.2 It is highly related to FGF-16.
FGF-9 has been shown to mediate its effects by binding to FGF receptors. It efficiently activates the FGFR2c splice form of FGFR2 and the FGFR3b and FGFR3c splice isoforms of FGFR3.3 FGF-9 is a high affinity, heparin dependent ligand for FGFR3 and FGFR2 but not for FGFR1 and FGFR4.4

Antigen Details

References & Citations

1. Imamura T. et al. (1999)J Biol Chem 274: 29352 2. Miyamoto M et al. (1993)Molecular Cellular Biology 13: 4251 3. Santos-Ocampo S et al. (1996)Journal of Biological Chemistry 271: 1726 4. Hecht D et al. (1995)Growth Factors 12: 223
Indirect Elisa Protocol
N
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.