Anti-Mouse ICOS (Clone C398.4A) – Purified (PhenoCyler-Fusion (CODEX)® Ready)
Anti-Mouse ICOS (Clone C398.4A) – Purified (PhenoCyler-Fusion (CODEX)® Ready)
Product No.: I-2012
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Clone C398.4A Target ICOS Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD278 Isotype IgG Applications IHC FF , PhenoCycler® |
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CODEX® DetailsValidation Notes Clone C398.4A has been validated for use on CODEX® using Mouse FF tissue. Tissue Screened MCA Sarcoma (Tumor) Tissue Preparation FF (Fresh Frozen) Antibody and Reporter DetailsReactivity Species Mouse Host Species Armenian Hamster Concentration 0.5 mg/ml Immunogen Human Retinoblastoma tumor Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4. Storage and Handling This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Applications and Recommended Usage? Quality Tested by Leinco CODEX® This ICOS (Clone C398.4A) antibody is formulated to simplify the antibody preparation needed when performing a CODEX® barcode conjugate. The suggested concentration is 0.5 mg/ml. Country of Origin USA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionAntigen Distribution ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages. Background CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases. Antigen DetailsProtein Ligand/Receptor B7h/B7RP-1/GL-50 PubMed Technical Protocols PhenoCycler® |
Formats Available
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Prod No. | Description |
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I-2012 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
