Anti-Mouse ICOS (Clone C398.4A) – Purified (PhenoCyler-Fusion (CODEX)® Ready)

Anti-Mouse ICOS (Clone C398.4A) – Purified (PhenoCyler-Fusion (CODEX)® Ready)

Product No.: I-2012

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Clone
C398.4A
Target
ICOS
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD278
Isotype
IgG
Applications
IHC FF
,
PhenoCycler®

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Product Size
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CODEX® Details

Validation Notes
Clone C398.4A has been validated for use on CODEX® using Mouse FF tissue.
Tissue Screened
MCA Sarcoma (Tumor)
Tissue Preparation
FF (Fresh Frozen)

Antibody and Reporter Details

Reactivity Species
Mouse
Host Species
Armenian Hamster
Concentration
0.5 mg/ml
Immunogen
Human Retinoblastoma tumor
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4.
Storage and Handling
This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications and Recommended Usage?
Quality Tested by Leinco
CODEX® This ICOS (Clone C398.4A) antibody is formulated to simplify the antibody preparation needed when performing a CODEX® barcode conjugate. The suggested concentration is 0.5 mg/ml.
Country of Origin
USA
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Antigen Distribution
ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
Background
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

Antigen Details

Protein
Ligand/Receptor
B7h/B7RP-1/GL-50
PubMed
IHC
PhenoCycler®

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.