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Anti-Mouse γ/δ T-Cell Receptor (TCR) Fluorescein (FITC)

Monoclonal Antibody


Prod. No.:T131
Clone:UC7-13D5
Isotype:Armenian Hamster IgG
Conc.:0.5 mg/ml
Pkg. Size:100 µg, 500 µg
Storage:2-8°C Detailed storage instructions below.
Description
Specificity:
The anti-mouse γ/δ T-cell receptor antibody reacts with all mouse TCR γ/δ heterodimers.

Antigen Distribution:
γδ TCR expression is observed on a subset of cells in the thymus, intestinal epithelium, skin, liver, peripheral lymphoid tissues, and peritoneum. The γδ TCR is involved in the antigen recognition of some bacterial or tumor-associated antigens presented by MHC class I.

Background:
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Reporter Molecule:
Fluorescein (FITC) is a small fluorescent organic molecule with a molecular weight of 473 daltons with an absorbance maximum of ~492 nm and an emission maximum of ~518 nm.

Known Species Cross Reactivity: Ms+
Host Species
Armenian Hamster
Formulation
This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.


Country of Origin
USA
References
Bluestone, J. A. et al. (1991) Immunol. Rev. 120:5
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