Mikrogen Diagnostik recomLine HantaPlus IgG Lateral Strip Test Kit

Strip-Immunoassay with antigens produced by recombinant techniques for the detection of IgG and IgM antibodies against Hantavirus (serotypes Puumala (PuN), Sin Nombre (SinN), Hantaan (HaN), Dobrava (DobN) and Seoul (SeoN)) as well as Sandfly Fever Virus (SFFV) serotypes Toscana and Sicilian.

Most of the Bunyaviruses can be found in the tropics and subtropics. An exception are the genera of Hantavirus und Phlebovirus which are also represented in Europe as well.

Hantavirus: Different rodent species are vectors for the different hantavirus serotypes Puumala, Sin Nombre, Dobrava, Hantaan and Seoul. Many other serotypes are described in literature to be found in isolated areas. Based on a significant homology within the N-terminal part of the virus nucleocapsid antigen, hantaviruses can be devided in two serological groups, Puumala and Sin Nombre, and the group of Hantaan, Dobrava and Seoul. Hantaviruses are transmitted via stirred and inhaled dust, contaminated with rodents droppings. Hantavirus outbreaks regularly monitored every two to three years are very likely interconnected with an excessive food supply for the vector animals (rodents) and their proliferation. Typical peaks in case numbers can be related to holiday seasons and spring-cleaning activities, like cleaning basement, outbuilding or summer houses with unattended rodent infestation. There are no cases described for human to human transmission. The onset of a hantavirus infection is characterized by flu-like symptoms. The Puumalavirus prevelant in Europe can cause renal failures requiring hemodialysis and intensive care treatment. This Nephropathia epidemica (NE), describes a moderate form of the hemorrhagic fever with renal syndrom (HFRS), caused by infections with the virus types Dobrava, Hantaan and Seoul. The lethality of a Puumala infection is reported to be less than 1%. An infection with Sin Nombre or Andes virus may result in a severe Hantavirus Pulmonary Syndrom (HPS) with lethality rates reported over 30%.

Sandfly Fever Virus (SFFV): A few Bunyaviruses in Europe are transmitted by the Sandfly (Phlebotomus pappatasi), which is present in the Mediterranean area. Sandfly Fever, synonym Pappatasi Fever, is characterized by fever symptoms and headache. More severe courses with fever, strong, frontal headache and an aseptic meningitis with neurological symptoms are described for infections with the serotypes Toscana and Sicilian.

Research Use Only.

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