Recombinant Human Growth Hormone

Growth hormone (GH), also known as somatotropin, is a peptide hormone that regulates growth, cell proliferation, and tissue regeneration. It is synthesized and secreted by somatotroph cells in the anterior pituitary gland and released in a pulsatile manner under the control of hypothalamic growth hormone–releasing hormone (GHRH) and somatostatin (SST).

GH influences both metabolic and immune processes, supporting thymic function, T and B cell development, cytokine regulation, and myeloid cell activity. It also promotes lipolysis, amino acid uptake, protein synthesis, and lactation, reflecting its central role in anabolic growth and repair mechanisms.

The ED50, as measured by a rat lymphoma NB2-11 cell proliferation assay, is less than 0.1 ng/ml.

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Met

Lyophilized

The predicted molecular weight of Recombinant Human GH is Mr 22 kDa.

22

GH protein is lyophilized from a 0.2 µm filtered concentrated solution formulated in phosphate buffer containing mannitol and glycine.

It is recommended to reconstitute the lyophilized GH in sterile 18 MΩ·cm water at a concentration of at least 100 µg/ml. The reconstituted solution may be further diluted in other aqueous buffers as required.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one week or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Note: For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Next Day Ambient

1. Lin-Su, K. et al. (2002) Rev. Endocr. Metab. Disord. 3:313
2. Hattori, N. et al. (2009) Growth Horm. IGF Res. 19:187
3. Goffin, V. et al. (1996) Endocrine Rev. 17:385
4. Le Roith, D. et al. (2001) Endocrine Rev 22:53