Recombinant Human MIG (CXCL9)

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. Mig may be important not only to recruit T cells to peripheral inflammatory sites, but also in some cases to maximize interactions among activated T cells, B cells, and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens.¹

The biological activity of Human MIG was determined by its ability to chemoattract mCXCR3 transfected mouse BaF/3 cells. The expected ED₅₀ for this effects is typically 0.1 - 0.4 μg/ml.

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Thr23

Lyophilized

The predicted molecular weight of Recombinant Human MIG is Mr 11.7 kDa.

11.7

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Farber, JM. et al. (2002) J. Immunol. 169: 1433