Recombinant Human SDF-1α/CXCL12
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BackgroundSDF-1α, also called CXCL12, is one of two splice variants made by a wide variety of cells when stimulated by inflammatory cytokines such as, TNF, IL-1 or LPS. SDF-1α signals through the G protein-couple receptor, CXCR4, to recruit activated leukocytes. Human and mouse SDF-1α share 99% sequence identity. Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity The activity is determined by its ability to chemoattract human peripheral T cells at 10 - 75 ng/mL. This corresponds to an expected specific activity of 1 x 105 units/mg. Protein Accession No. Amino Acid Sequence KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human SDF-1α is Mr 8.0 kDa. Predicted Molecular Mass 8.0 Formulation Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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